No longer available - please browse our other product offerings. Thank you.

Zappetite - The Ultimate Appetite Suppressant is a unique and novel formula containing new ingredients designed to eradicate appetite, burn calories at rest, and increase thermogenesis with NO stimulant side effects. There is no other formula that contains the revolutionary combination of ingredients found in Zappetite. OEA (Oleoylethanolamide) is a cannabinoid receptor agonist that has been clinically proven to decreases appetite and body weight. Hoodia Gordonii is a plant found in southern Africa containing the P57 compound, which is known for its amazing appetite suppressing activity. Simondslim contains Jojoba seed extract standardized for Simmondsin, which has been demonstrated to dramatically decrease appetite and body weight. LotuSlim an ingredient exclusive to Zappetite is a standardized extract of Lotus Leaf, which has been shown to liberate fat stores and decrease body weight.

Evodiamine is vanilloid receptor agonist that utilizes the same receptor as the red pepper ingredient capsaicin, which increases body temperature and caloric expenditure. Angelica dhaurica is another ingredient exclusive to Zappetite contains the first standardized extract of imperatorin, which has been shown to act an oxidative uncoupler, increase fat burning hormones and decrease fat storing hormones. Sceletium tortuosum is yet another ingredient exclusive to the Zappetite formula. Traditionally know as the 'feel good herb' because of its mood enhancing effects sceletium was used sparingly because of its 'side effect' of a loss of appetite! There is no other formula currently in existence that possesses the appetite crushing and thermogenic properties of ZAPPetite. ZAPP your appetite away right now with Zappetite.

Oleoylethanolamide

Oleyoethanolamide is a naturally occuring amide of oleic acid and ethanolamine, synthesized in the human body primarily by upper part of the small intestine especially when the meal is rich with fats.

It belongs in a family of naturally occurring fatty acid ethanolamides(FAEs), present in both animal and plant organisms[1,2]. It received little attention till it was found that a member of the same family, anandamide, served as an endogenous ligand for cannabinoid receptors(3,4) the G-protein-coupled receptors targeted by Ä9-tetrahydrocannabinol in marijuana [5, 6].

It was found that in the duodenum and jejunum of rats and mice, OEA levels change in response to nutrient status- they are lower in food-deprived than free-feeding animals, and return to normal values upon refeeding [7]. This changes happen in the upper part of the small intestine-the part most associated with food intake and feeding behaviour[8]. OEA levels in the rodent small intestine also display diurnal fluctuations. They are higher during the daytime, when animals are satiated, and lower during the night, when they are awake and actively feeding [9]. These findings led researchers to conclude that OEA will affect appetite and feeing behaviour. Indeed, studies in mice have shown OEA to suppress appetite in a time and dosage dependent way[10-13].

Apart from it's appetite suppressing abilities, OEA is also a potent PPAR-a agonist. PPAR-a receptors are a class of nuclear receptors that are also the target for antihyperlipidemic drugs whose stimulation induces increased fatty acid catabolism, lower blood lipid levels and lowered body weight gain[14,15]. In fact, OEA is such a powerful PPAR-a agonist that it's agonistic action exceeds that of many other PPAR-a agonists[16].

Hoodia Gordonii

Hoodia Gordonii is a cactus-like plant from South Africa, from the large Milkweed family. Reports and interviews from South Africa natives suggested that the plant could assuage both the feeling and 'pangs' of hunger that occurred during the long treks.[18] Animal studies compromised on extracts from various parts of the plant have shown that Hoodia Gordonii extract can reduce appetite, balance blood sugar levels and promote weight loss. Animal safety studies have not shown any deleterious side effects independent of the weight loss itself. The putative active component in these sap extracts is a trirhabinoside, known as P57AS3. ZAPPED is currently the only supplement on the market containing Hoodia Gordonii extract that has been tested positive for P57. The mechanism of action of P57 was studied in rats[19]. It was found that P57 increases ATP concentration in the hypothalamus(the part of the brain that among other thing modulates feeding, body temperature, sleep and hormonal release) by 50-150%. It has been found that following long time hypo caloric diets, hypothalamic ATP levels drop by 40-60%, which may very well lead to decreased hormonal production, sleep problems, tiredness e.t.c. Summing up current evidence, apart from the appetite suppression, P57 is very important from combating the side effects following caloric-restricted diets.

Slimondslim

The jojoba plant (Simmondsia chinensis) is a shrub cultivated in arid and semiarid regions for its oil containing nuts. When the leftovers of oil production (jojoba meal) were supplemented to animal food, a profound reduction in food intake was observed. It was demonstrated that simmondsin, a glycoside, was responsible for the appetite-reducing effects of jojoba meal [20]. No major toxic effects have been noted after long-term administration of low doses of simmondsin inducing a sustained food intake and growth reduction in growing rats [21,22]. The food intake-reducing activity seems to be at least in a great part mediated via the vagal nerve since vagotomy significantly reduces the simmondsin-induced food intake inhibition [23]. Further studies on rats have shown the anorectic effects to be dose-dependent, improve with continued simmondsin administration, are greater for overfed rats compared to underfed rats and can also induce taste aversion to craved foods like a saccharin solution[24]. Simmondsin is powerful agent to reduce craving for food.

LotuSlim

The Lotus Leaf (Nelumbo nucifera)is a traditional herb, primarily found in India. Studies have also demonstrated that it possesses potent antioxidant actions [25]. A study on rats has demonstrated that Lotus Leaf can lower heightened glucose levels, improve glucose tolerance, potentiate insulin activity (both endogenous and exogenous) and reduce glucose absorption [28].

Evodia rutaecarpa

Evodiamine, isolated from the dry unripened fruit of Evodia rutaecarpa Bentham. Evodiamine also possesses antioxidant activities[30]. The exact mechanisms of action of Evodiamine are many and still under research. In a study in rats[32], evodiamine demonstrated potent activity as a Cholecystokinine(CCK) agonist. The functions of cholecystokinin (CCK) include stimulation of pancreatic enzyme secretion and inhibition of gastric emptying[33]as well as suppression of food intake [33]. Thus, evodiamine can extend the satiating effect of food by slowing food emptying and reduce overall food intake. Evodiamine also exerts it's fat loss actions through stimulation of the vallinoid receptors, in the same way as capsaicin.[34] In a study performed on rats , Evodiamine would induce heat loss and heat production at the same time and dissipate food energy, preventing the accumulation of perivisceral fat and the body weight increase.[34]

Angelica Dhaurica

Angelica dahurica Bentham et Hooker (Umbelliferae) is a perennial herb distributed in the whole area of Korea. From various phytochemical studies, it has now been established that the majority of Angelica species contain quite high amounts of biologically active coumarins, predominantly simple- and furano- coumarins like umbelliprenin [36], bergapten, [37] imperatorin [38], isoimperatorin [39], byakangelicin [40], etc., and other active components. Angelica Dhaurica's furanocumarines imperatorin, isoimperatorin, and oxypeucedanin are proven to have potent acetylcholynesterase inhibitory activity. Acetylcholynesterase is the enzyme that breaks up the neurotransmitter acetylcholine into acetic acid and choline. Among other things, acetylcholine dilates and relaxes blood vessels, which allows easier removal of fatty acids from adipose cells and also increases c-GMP concentration in fat cells by up to 350% in vitro.[41] Furanocoumarins such as oxypeucedanin hydrate, bergapten, xanthotoxin, imperatorin and phellopterin can also activate adrenalin-induced lipolysis. Imperatorin, oxypeucedanin hydrate and phellopterin also activate ACTH-induced lipolysis. Byakangelicin, neobyakangelicin and isopimpinellin strongly inhibite insulin-stimulated lipogenesis.[42]

Sceletium tortuosum

Sceletium Tortuosum Herba (kougoed) is a traditional herb found mainly in the Western and Eastern Cape provinces, from Namaqualand to Montagu. Sceletium species have been shown to contain at least 9 indole alkaloids, belonging to one of three structural types. In S. tortuosum (1-1.5% alkaloids) mesembrine appears to be most abundant (0.3% and 0.86% have been reported, respectively, in leaf and stem). Mesembrenone and 4'-O-demethylmesembrenol are also present. Tortuosamine, also isolated from S. tortuosum, represents a second structural type in which the pyrrole ring is opened. Alkaloid levels appear to fluctuate seasonally and may be highest in late spring/early summer; this is the time when plants are traditionally gathered and prepared for use. [44] There are many reports in the literature concerning the activity and use of 'kougoed' by the indigenous peoples.' One of the most reputed 'side effects' (considered negative by the indigenous people) was loss of appetite [45].

References

1. Kuehl F. A., Jacob T. A., Ganley O. H., Ormond R. E. and Meisinger, M. A. P. (1957) The identification of N-(2-hydroxyethyl)-palmitamide as a naturally occurring anti-inflammatory agent. J. Am. Chem. Soc. 79: 5577-5578
2. Bachur N. R., Masek K., Melmon K. L. and Udenfriend S. (1965) Fatty acid amides of ethanolamine in mammalian tissues.J. Biol. Chem. 240: 1019-1024
3. Devane W. A., Hanus L., Breuer A., Pertwee R. G., Stevenson L A., Griffin G. et al. (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946-1949
4. Di Marzo V., Fontana A., Cadas H., Schinelli S., Cimino G., Schwartz J. C. et al. (1994) Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 372: 686-691
5. Matsuda L. A., Lolait S. J., Brownstein M. J., Young A. C. and Bonner T. I. (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564
6. Munro S., Thomas K. L. and Abu-Shaar M. (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365: 61-65
7. Rodríguez de Fonseca F., Navarro M., Gómez R., Escuredo L., Nava F., Fu J. et al. (2001) An anorexic lipid mediator regulated by feeding. Nature 414: 209-212
8. Ritter R. C. (2004) Gastrointestinal mechanisms of satiation forfood. Physiol. Behav. 81: 249-273
9. Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez de Fonseca F. et al. (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425: 90-93
10. Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez de Fonseca F. et al. (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425: 90-93
11. Oveisi F., Gaetani S., Eng K. T. and Piomelli D. (2004) Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration. Pharmacol. Res. 49: 461-466
12. Nielsen M. J., Petersen G., Astrup A. and Hansen H. S. (2004) Food intake is inhibited by oral oleoylethanolamide. J. Lipid. Res. 45: 1027-1029
13. Kay B. M. and Ritter R. C. (2004) Oleoylethanolamide induces rapid reduction of short-term food intake in intact and vagotomized rats. Program No. 427.12, Society for Neuroscience, Washington, DC, online
14. Berger J. and Moller D. E. (2002) The mechanisms of action of PPARs. Annu. Rev. Med. 53: 409-435
15. Willson T. M., Brown P. J., Sternbach D. D. and Henke B. R. (2000) The PPARs: from orphan receptors to drug discovery. J.Med. Chem. 43: 527-550
16. Regulation of food intake by oleoylethanolamide J. LoVermea, S. Gaetania,c, J. Fua, F. Oveisia, K. Burtona and D. Piomellia,b,* a Department of Pharmacology, University of California, Irvine, California 92697-4260 (USA),Fax: +1 949 824 6305
17. Guzmán M., Lo Verme J., Fu J., Oveisi F., Blazquez C. andPiomelli D. (2004) Oleoylethanolamide stimulates lipolysisby activating the nuclear receptor peroxisome proliferatoractivated receptor alpha (PPAR-alpha). J. Biol. Chem. 279: 27849-27854
18. P. Bruyns, A revision of hoodia and lavrania (Asclepidaceae-Stapeliaeae Botanische Jahrbucher:fuer), Syst. Pflanzenges. Pflanzengeogr. 115 (1993) 145-270.
19. Brain Research 1020 (2004) 1 -11 Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside David B. MacLean*, Lu-Guang Luo
20. Booth AN, Elliger CA, Wain Jr AC. Isolation of a toxic factor from jojoba meal. Life Sci 1974;15:1115- 20.
21. Cokelaere M, Cauwelier B, Cokelaere K, Flo G, Houache N, Lievens S, et al. Hematological and pathological effects of 0.25% purified simmondsin in growing rats. Ind Crops Prod 2000;12:165- 71.
22. Cokelaere M, Daenens P, Decuypere E, Flo G, Ku¨hn E, Van Boven M, et al. Reproductive performance of rats treated with defatted jojoba meal or simmondsin before or during gestation. Food Agric Toxicol 1998;36:13- 9.
23. Swank M, Sweatt J. Increased histone acetyltransferase and lysine acetyltransferase activity and biphasic activation of the ERK/RSK cascade in insular cortex during novel taste learning. J Neurosci 2001; 21(10):3383- 91.
24. Simmondsin: effects on meal patterns and choice behavior in rats Sylvia Lievensa, Gerda Floa, Eddy Decuypereb, Maurits Van Bovenc, Marnix Cokelaerea,*
25. Antioxidant Activity of Methanol Extract of the Lotus Leaf (Nelumbo nucifera Gertn.) Ming-Jiuan Wu, Lisu Wang and Ching-Yi Weng Institute of Biotechnology, Chia-Nan University of Pharmacy and Science
26. Journal of Ethnopharmacology 46 (1995) 125-129 Short communication Traditional Chinese medicine in treatment of hyperlipidaemia Birgitte la Cour *a, Per MOlgaard a, Zhao Yi baDepartment of Pharmacognosy, 2 Universitetsparken, 2100 Copenhagen, Denmark bGuangxi College of Traditional Chinese Medicine. 21 Ming Xiu Road, Nanning, 530001 Guangxi, P.R China
27. Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids Yoshiki Kashiwada,a,* Akihiro Aoshima,a Yasumasa Ikeshiro,a Yuh-Pan Chen,b Hiroshi Furukawa,c Masataka Itoigawa,d Toshihiro Fujioka,e Kunihide Mihashi,e L. Mark Cosentino,f Susan L. Morris-Natschkeg and Kuo-Hsiung Leeg,* aFaculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata 950-2081, Japan
28. Journal of Ethnopharmacology 58 (1997) 207 213 Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats Pulok K. Mukherjee, Kakali Saha, M. Pal, B.P. Saha * Department of Pharmaceutical Technology, Faculty of Engineerb~g and Technology, Jadavpur b~iversity, Calcutta 700 032, India
29. Tang, W., Eisenbrand, G., 1992. Evodia rutaecarpa (Juss.) Benth. In: Tang, W., Eisenbrand, G. (Eds.), Chinese Drugs of Plant Origin. Springer Verlag, New York, pp. 509-514.
30. Chiou, W.F., Sung, Y.J., Liao, J.F., Shum, A.Y., Chen, C.F., 1997. Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages. J. Nat. Prod. 60, 708- 711.
31. Journal of Ethnopharmacology, 27 0989) 185- 192 Elsevier Scientific Publishers Ireland Ltd.185 ANTIANOXIC ACTION OF EVODIAMINE, AN ALKALOID IN EVODIA RUTAECARPA FRUIT JOHJI YAMAHARA, TOSHIMASA YAMADA, TETSUYA KITANI, YOSHIKAZU NAITOH and HAJIME FUJIMURA
32. Effects of evodiamine on gastrointestinal motility in male rats Chiu-Lung Wua, Chen-Road Hungb, Full-Young Changc, Lie-Chwen Lind, K.-Y. Francis Paue, Paulus S. Wanga,*
33. (Debas et al., 1975; Jin et al., 1994),
34. Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, Kamiya T. Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med. 2001 Oct;67(7):628-33. PMID: 11582540 [PubMed - indexed for MEDLINE]
35. (Soka, 1985).
36. Kim, D. K.; Lim, J. P.; Yang, J. H.; Eom, D. O.; Eun, J. S.; Leem, K. H. Archives of Pharmacal Research, 2002, 25, 856.
37. Kang, S. Y.; Lee, K. Y.; Sung, S. H.; Park, M. J.; Kim, Y. C.Journal of Natural Products, 2001, 64, 683.
38. Chen, Y. F.; Tsai, H. Y.; Wu, T. S. Planta Medica, 1995, 61, 2.
39. Inamori, Y.; Baba, K.; Tsujibo, H.; Taniguchi, M.; Nakata, K.;, Kozawa, M. Chemical and Pharmaceutical Bulletin, 1991,39, 1604.
40. Yan, T. Y.; Hou, A. C.; Sun, B. T. Zhong Xi Yi Jie He Za Zhi., 1987, 7, 161.
41. Guanosine 3':5'-Cyclic Monophosphate and the Action of Insulin and Acetylcholine Gennaro Illiano, Guy P. E. Tell, Marvin I. Siegel, and Pedro Cuatrecasas
42. Effects of various coumarins from roots of Angelica dahuria on actions of adrenaline, ACTH and insulin in fat cells. Kimura Y. et al. Journal of Medicinal Plant Research 45: 183-187, 1982.
43. Coumarins and antiplatelet aggregation constituents from Formosan Peucidanum japonicum. Chen IS. et al. Phytochemistry 41: 525-530, 1996.
44. Smith, M.T., Field, C.R., Crouch, N.R. and Hirst, M. (1998). The distribution of mesembrine alkaloids in selected taxa of the Mesembryanthemaceae and their modification in the Sceletium derived 'kougoed.' Pharmaceutical Biology 36(3): 173-179 and refs. therein.
45. (Marloth, 1913)
46. http://www.plantzafrica.com/medmonographs/scelettort.pdf